I must regretfully retract my previous assertion that Andy Serkis has two minifigs (Gollum; The Witch King)
I will disagree, Andy Serkis played Gollum in motion capture.
He also mocap king kong and i think there is lego studio set with king kong.
Also does the minifigs count ? http://minifigs.me/
Because johnny depp’s got a whole set ! http://minifigs.me/depp
How about Robert doney jr as Tony Stark and Iron man ? They both got a separate minifigure.
I would also add Bill Nighy: Davy Jones (PoC) & Rufus Scrimgeour (HP)